Publications
Take a closer look to all publications authored by the Lewis Lab to gain deeper insights into our research and contribution
Recent Publications
A new antibiotic selectively kills Gram-negative pathogens
Nature
The Science of Antibiotic Discovery
Cell
Stochastic Variation in Expression of the Tricarboxylic Acid Cycle Produces Persister Cells
mBio
Computational identification of a systemic antibiotic for Gram-negative bacteria
Nature Microbiology
The Role of Integration Host Factor in Escherichia coli Persister Formation
mBio
Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
Nature Chemical Biology
Teixobactin kills bacteria by a two-pronged attack on the cell envelope
Nature
A Selective Antibiotic for Lyme Disease
Cell
Bacterial persisters are a stochastically formed subpopulation of low-energy cells
PLoS Biology
The antibiotic darobactin mimics a β-strand to inhibit outer membrane insertase
Nature
A Distinct Microbiome Signature in Posttreatment Lyme Disease Patients
mBio
Novel Antimicrobials from Uncultured Bacteria Acting against Mycobacterium tuberculosis
mBio
GABA-modulating bacteria of the human gut microbiota
Nature Microbiology
Identifying Vancomycin as an effective antibiotic for killing Borrelia Burgdorferi
Antimicrob Agents Chemother
A genetic determinant of persister cell formation in bacterial pathogens
J Bacteriol
ATP dependent persister formation in Escherichia coli
mBio
Persister formation in Staphylococcus aureus is associated with ATP depletion
Nature Microbiology
HipAB-promoter structures reveal basis of heritable multidrug tolerance
Nature
Borrelia burgdorferi, the Causative agent of Lyme Disease, Forms Drug-Tolerant Persister Cells
Antimicrob Agents Chemother
Genetic basis of persister tolerance to aminoglycosides in Escherichia coli
mBio
A new antibiotic kills pathogens without detectable resistence
Nature
Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
Chemistry & Biology
A Screen for and Validation of Prodrug Antimicrobials
Antimicrob Agents Chemother
Tolerance of Escherichia coli to Fluoroquinolone Antibiotics Depends on Specific Components of the SOS Response Pathway
Genetics
Activated ClpP kills persisters and eradicates a chronic biofilm infection
Nature
A problem of persistence: still more questions than answers?
Nat Rev Microbial
Platforms for antibiotic discovery
Nat Rev Drug Discov
Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species
Science
Role of Oxidative Stress in Persister Tolerance
Antimicrob Agents Chemother
Antibiotics: Recover the lost art of drug discovery
Nature
Characterization and Transcriptome Analysis of Mycobacterium tuberculosis Persisters
mBio
Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis
Journal of Bacteriology
Siderophores from Neighboring Organisms Promote the Growth of Uncultured Bacteria
Chemistry & Biology